10 Mg Morphine Sulphate Pentahydrate Recreational Dose
GeneralHigh Alert Medication: This medication bears a heightened risk of causing significant patient harm when it is used in error.REMS Drug.Pronunciation:mor-feenTrade Name(s). Arymo ER. Astramorph. AVINza. Doloral. Duramorph.
Embeda. Infumorph. Kadian.
M-Eslon. Morphabond ER. Morphine EPD. Morphine Extra Forte.
Morphine Sulfate Dosage Chart
Morphine Forte. Morphine HP. Morphine LP Epidural. M.O.S. M.O.S.-S.R. MS Contin.
MS Contin SRT. Roxanol. StatexTher. Class.opioid agonistsControlled Substance Schedule: II.
PharmacokineticsAbsorption: Variably absorbed (about 30%) following oral administration. More reliably absorbed from rectal, subcut, and IM sites. Following epidural administration, systemic absorption and absorption into the intrathecal space via the meninges occurs.Distribution: Widely distributed.
Crosses the placenta; enters breast milk in small amounts.Protein Binding: Premature infants. Route/DosageLarger doses may be required during chronic therapyPO: Rect: (Adults ≥50 kg): Usual starting dose for moderate to severe pain in opioid-naive patients– 30 mg q 3–4 hr initially or once 24-hr opioid requirement is determined, convert to extended-release morphine by administering total daily oral morphine dose every 24 hr (as Kadian or other ER capsules), 50% of the total daily oral morphine dose every 12 hr (as Arymo ER, Kadian, Morphabond, MS Contin ), or 33% of the total daily oral morphine dose every 8 hr (as Arymo ER, MS Contin ).
See equianalgesic chart,. Dose of ER capsules (not Kadian ) should not exceed 1600 mg/day because of fumaric acid in formulation.PO: Rect: (Adults and Children 1 mo): Prompt-release tablets and solution– 0.2–0.5 mg/kg/dose q 4–6 hr as needed. Controlled-release tablet– 0.3–0.6 mg/kg/dose q 12 hr.IM: IV: SC: (Adults ≥50 kg): Usual starting dose for moderate to severe pain in opioid-naive patients– 4–10 mg q 3–4 hr. MI– 8–15 mg, for very severe pain additional smaller doses may be given every 3–4 hr.IM: IV: SC: (Adults and Children 1 mo): Continuous infusion, postoperative pain– 0.01–0.04 mg/kg/hr. Continuous infusion, sickle cell or cancer pain– 0.02–2.6 mg/kg/hr.IV: Neonates Continuous infusion– 0.01–0.03 mg/kg/hr.Epidural: (Adults) Intermittent injection– 5 mg/day (initially); if relief is not obtained at 60 min, 1–2 mg increments may be made (total dose not to exceed 10 mg/day.
Continuous infusion– 2–4 mg/24 hr; may ↑ by 1–2 mg/day (up to 30 mg/day).Epidural: (Children 1 mo): 0.03–0.05 mg/kg, maximum dose: 0.1 mg/kg or 5 mg/24 hr. Use preservative-free formulation.IT: (Adults) 0.2–1 mg. Use preservative-free formulation. Assessment. Assess type, location, and intensity of pain prior to and 1 hr following PO, subcut, IM, and 20 min (peak) following IV administration.
When titrating opioid doses, increases of 25–50% should be administered until there is either a 50% reduction in the patient's pain rating on a numerical or visual analogue scale or the patient reports satisfactory pain relief. When titrating doses of short-acting morphine, a repeat dose can be safely administered at the time of the peak if previous dose is ineffective and side effects are minimal. Patients on a continuous infusion should have additional bolus doses provided every 15–30 min, as needed, for breakthrough pain. The bolus dose is usually set to the amount of drug infused each hour by continuous infusion. Patients taking extended-release morphine may require additional short-acting opioid doses for breakthrough pain.
Doses of short-acting opioids should be equivalent to 10–20% of 24 hr total and given every 2 hr as needed. An equianalgesic chart (see ) should be used when changing routes or when changing from one opioid to another. High Alert: Assess level of consciousness, BP, pulse, and respirations before and periodically during administration.
If respiratory rate is. Implementation. High Alert: Do not confuse MS Contin (morphine sulfate) with Oxycontin (oxycodone). Do not confuse morphine (non-concentrated oral liquid) with morphine (concentrated oral liquid). High Alert: Do not confuse morphine with hydromorphone–errors have resulted in death. Use only preservative-free formulations for neonates, and for epidural and intrathecal routes in all patients. Abuse deterrent: Embeda is an abuse deterrent formulation that contains naltrexone which remains inactive unless the product is crushed or diluted.
Morphabond ER and Arymo ER are abuse deterrent formulations that are difficult to crush and, if crushed result in a gel. Explain therapeutic value of medication prior to administration to enhance the analgesic effect. Regularly administered doses may be more effective than prn administration. IV Administration.
IV: Solution is colorless; do not administer discolored solution. IV Push: Diluent: Dilute with at least 5 mL of sterile water or 0.9% NaCl for injection. Concentration: 0.5–5 mg/mL. Rate: High Alert: Administer 2.5–15 mg over 5 min. Rapid administration may lead to increased respiratory depression, hypotension, and circulatory collapse. Continuous Infusion: Diluent: May be added to D5W, D10W, 0.9% NaCl, 0.45% NaCl, Ringer's or LR, dextrose/saline solution, or dextrose/Ringer's or LR. Concentration: 0.1–1 mg/mL or greater for continuous infusion.
Rate: Administer via infusion pump to control the rate. Dose should be titrated to ensure adequate pain relief without excessive sedation, respiratory depression, or hypotension. Patient/Family Teaching. Instruct patient how and when to ask for pain medication. May cause drowsiness or dizziness. Caution patient to call for assistance when ambulating or smoking and to avoid driving or other activities requiring alertness until response to medication is known.
Advise patient that morphine is a drug with known abuse potential.
10 Mg Morphine Sulphate Pentahydrate Recreational Dose For Dogs
Hey druggit, so i have six 10MG (60MG) pills of morphine sulfate in my possession. I have had the same pills before but only 3 of them (30MG) which i tried to snort, but it hurt a lot of and i pretty much failed, and just ingested the other 2, but never ended up feeling anything. Anyway i'm wondering if i just take the 60MG orally will it be too much? Whats a regular good dose for this stuff? I'm a girl, and i dont have a tolerance as i never do opiates.
Also how long do you think that would last?Any advice would be appreciated.